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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本富山医科药科大学
学位：博士
所在单位：化工学院
学科：药物化学. 药物分析学
办公地点：西部新校区G-302室（制药科学与技术学院）
联系方式：84986195
电子邮箱：zyzhao@dlut.edu.cn
环巴胺类似物的合成及体外抗肿瘤细胞活性研究
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论文类型：期刊论文
发表时间：2022-07-03
发表刊物：天然产物研究与开发
卷号：27
期号：5
页面范围：890-895
ISSN号：1001-6880
摘要：Cyclopamine is a steroid alkaloid with Hedgehog signal pathway
inhibitory activity and exhibits significant antitumoractivity. In this
study, cyclopamine analogues were synthesized by reduction, oxidation
and methylation from an available alkaloid, jervine. The structures of
the yielded compounds were determined by MS,1 D and 2D NMR. Structures
of compounds 4,9 and 10 have not been reported previously. The antitumor
activities of the 10 synthesized compounds against Aspc-1 and SGC-7901
cancer cells were evaluated by MTT method.
备注：新增回溯数据