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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本富山医科药科大学
学位：博士
所在单位：化工学院
学科：药物化学. 药物分析学
办公地点：西部新校区G-302室（制药科学与技术学院）
联系方式：84986195
电子邮箱：zyzhao@dlut.edu.cn
Syntheses of new chlorin derivatives containing maleimide functional group and their photodynamic activity evaluation
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论文类型：期刊论文
发表时间：2015-10-01
发表刊物：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
收录刊物：SCIE、PubMed、Scopus
卷号：25
期号：19
页面范围：4078-4081
ISSN号：0960-894X
关键字：Chlorin derivatives; Chlorin e6; Photo cytotoxic activity; Singlet oxygen
摘要：Nine new chlorin derivatives containing maleimide functional group and amino acid residue with chlorin e6 scaffold (compounds 1-6) or pheophorbide a scaffold (compounds 7-9) were synthesised from chlorophyll a. The all nine derivatives demonstrated increased photo cytotoxic activity in HepG2 cell (IC50 3.2-20.5 mu M) comparing with chlorin e6 and its trimethyl ester. Their photo cytotoxicities were approximately dependent on their abilities to produce singlet oxygen (O-1(2)) in the cells. (C) 2015 Published by Elsevier Ltd.