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论文类型：期刊论文

发表时间：2012-05-07

发表刊物：JOURNAL OF ETHNOPHARMACOLOGY

收录刊物：SCIE、PubMed、Scopus

卷号：141

期号：1

页面范围：183-186

ISSN号：0378-8741

关键字：Veratrum patulum L.; Steroidal alkaloids; Antithrombotic; Antiplatelet; Bleeding time

摘要：Ethnopharmacological relevance: Veratrum patulum L (Liliaceae) is used as one source of the Chinese traditional drug "Lilu" which has been used in the treatment of aphasia arising from apoplexy, wind type dysentery, headache, etc. for thousands of years.
   Aim of the study: To evaluate the antithrombotic effect of Veratrum patulum L (Liliaceae) total steroidal alkaloids (VpA) and explore the potential mechanisms.
   Materials and methods: The antithrombotic effect of VpA was evaluated in two experimental thrombosis models in rat. The potential antithrombotic mechanisms of VpA were explored by determining the coagulation parameters and platelet aggregation induced by various agonists. Cutting-tail rat model was used to evaluate the influence of VpA on bleeding time.
   Results: VpA significantly inhibit the formation of arterial and venous thrombosis and showed different inhibitory effect on the platelet aggregation induced by various agonists with the following potency order: collagen > ADP > thrombin. VpA showed no influence on the coagulation parameters in rat. But VpA decreased the cutting-tail bleeding time in rat.
   Conclusion: VpA possess antithrombotic effect on venous and arterial thrombosis. The antithrombotic effect of VpA is due to its inhibition to platelet aggregation, especially induced by collagen. (C) 2012 Elsevier Ireland Ltd. All rights reserved.