Release Time:2019-07-01  Hits:

Indexed by: Journal Article

Date of Publication: 2019-03-14

Journal: ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals: SCIE、EI、PubMed

Volume: 17

Issue: 10

Page Number: 2663-2669

ISSN: 1477-0520

Abstract: A method to access various multisubstituted indoles from propargylic alcohols and readily available enol nucleophiles by copper-catalyzed tandem annulation/enol nucleophilic addition has been developed. Compared to the expensive metal catalysts such as platinum, gold, silver, and palladium used previously, the most economical copper(I) catalyst could achieve this reaction efficiently. The fused heterocyclic compounds, pyrrolo[1,2-a] indoles, could be afforded by further transformation of the products. The allyl cation intermediate may be involved in the mechanism.