Release Time:2019-10-10  Hits:

Indexed by: Journal Article

Date of Publication: 2006-08-01

Journal: CHINESE CHEMICAL LETTERS

Included Journals: Scopus、ISTIC、SCIE

Volume: 17

Issue: 8

Page Number: 1125-1128

ISSN: 1001-8417

Key Words: lactic acid; 4-hydroxyproline; polyethylene glycol

Abstract: A series of poly(lactic acid-4-hydroxyproline-polyethylene glycol) (PLA-Hpr-PEG) copolymers were synthesized by direct melt copolymerization of D,L-lactic acid and 4-hydroxyproline with different feed amount of polyethylene glycol (PEG) 0.1%, 0.5%, 1% and 5%, respectively. The properties of these copolymers were characterized by using IR spectroscopy, proton nuclear magnetic resonance (H-1-NMR) spectroscopy, gel permeation chromatography (GPC), X-ray diffraction and differential scaning calorimetry (DSC). PLA-Hpr-PEG are amorphous copolymers. Copolymers showed increasing water uptake capacity with increasing PEG percentage in the feed, which result in an increasing degradable rate in phosphate buffer solution (pH 7.4) at 37 degrees C.