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Indexed by:期刊论文

Date of Publication:2006-08-01

Journal:CHINESE CHEMICAL LETTERS

Included Journals:SCIE、ISTIC、Scopus

Volume:17

Issue:8

Page Number:1125-1128

ISSN No.:1001-8417

Key Words:lactic acid; 4-hydroxyproline; polyethylene glycol

Abstract:A series of poly(lactic acid-4-hydroxyproline-polyethylene glycol) (PLA-Hpr-PEG) copolymers were synthesized by direct melt copolymerization of D,L-lactic acid and 4-hydroxyproline with different feed amount of polyethylene glycol (PEG) 0.1%, 0.5%, 1% and 5%, respectively. The properties of these copolymers were characterized by using IR spectroscopy, proton nuclear magnetic resonance (H-1-NMR) spectroscopy, gel permeation chromatography (GPC), X-ray diffraction and differential scaning calorimetry (DSC). PLA-Hpr-PEG are amorphous copolymers. Copolymers showed increasing water uptake capacity with increasing PEG percentage in the feed, which result in an increasing degradable rate in phosphate buffer solution (pH 7.4) at 37 degrees C.