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Copper-catalyzed cascade click/nucleophilic substitution reaction to access fully substituted triazolyl-organosulfurs

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Indexed by:Journal Papers

Date of Publication:2019-12-14

Journal:ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals:PubMed、SCIE

Volume:17

Issue:46

Page Number:9933-9941

ISSN No.:1477-0520

Abstract:A novel cascade click/nucleophilic substitution reaction is developed to access 4-heterofunctionalized fully substituted triazolyl-organosulfurs using thiocyanates as both leaving groups and organosulfur precursors. This method features high regioselectivities and board substrate scope. 33 examples are shown to demonstrate the structural diversity through the synthesis of fully substituted triazolyl-organosulfurs including triazolyl-thiocyanates, triazolyl-sulfinylcyanides, triazolyl-thioethers, triazolyl-thiols and triazolyl-disulfides from internal thiocyanatoalkynes.

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