Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2018-07-26

Journal: TETRAHEDRON

Included Journals: SCIE

Volume: 74

Issue: 30

Page Number: 4126-4133

ISSN: 0040-4020

Key Words: alpha-Benzoyloxylation; Phase-transfer catalysis; alpha-Hydroxylation; beta-keto amides; Acyloxy-functionalization

Abstract: A facile and efficient protocol for alpha-benzoyloxylation and alpha-hydroxylation of beta-keto amides by phase-transfer catalysis is presented. This methodology provides mild and practical access to a variety of alpha-oxygenated beta-keto amides. Furthermore, alpha-benzoyloxylation products can be easily converted into alpha-hydroxylation compounds, which are useful synthetic precursors of biological targets. (C) 2018 Elsevier Ltd. All rights reserved.