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Indexed by:期刊论文

Date of Publication:2016-03-03

Journal:ADVANCED SYNTHESIS & CATALYSIS

Included Journals:SCIE

Volume:358

Issue:5

Page Number:737-745

ISSN No.:1615-4150

Key Words:Cinchona alkaloid derivatives; enantioselectivity; alpha-hydroxylation; organocatalysis; synthetic methods

Abstract:The highly catalytic asymmetric alpha-hydroxylation of b-indanone esters and b-indanone amides using peroxide as the oxidant was realized with a new C-2' substituted Cinchona alkaloid derivatives. The two enantiomers of alpha-hydroxy-beta-indanone esters could be obtained by simply changing the oxidant. This protocol allows a convenient access to the cor-responding alpha-hydroxy-beta-indanone esters and a-hydroxy- b-indanone amides with up to 99% yield and 98% ee.