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Indexed by:期刊论文

Date of Publication:2016-01-01

Journal:GREEN CHEMISTRY

Included Journals:SCIE

Volume:18

Issue:20

Page Number:5493-5499

ISSN No.:1463-9262

Abstract:An efficient and enantioselective photo-organocatalytic alpha-hydroxylation of beta-dicarbonyl compounds using molecular oxygen was extended. This simple catalytic procedure is applicable to a range of beta-keto esters and beta-keto amides (30 examples) with a new series of C-2'-substituted phase transfer catalysts in good enantiopurity (up to 90% ee) and yield (up to 99%). Moreover, the reaction was successfully scaled up to gram quantity without any loss of enantioselectivity.