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Date of Publication:2019-01-01

Journal:化工学报

Volume:70

Issue:8

Page Number:3202-3209

ISSN No.:0438-1157

Abstract:Photocatalysis, asymmetric synthesis and molecular oxygen oxidation are combined with continuous reaction. Using a glass microreactor, a continuous reaction for asymmetric α-hydroxylation of β-keto ester compound is oxidized by 1O2 under visible light. The reaction is catalyzed by cinchona alkaloid phase transfer catalyst in gas-liquid-liquid heterogeneous system. The desired product is obtained in high yield (95%) and good enantio selectivity (87.0%) in microreactor. Compared with the batch reaction, continuous reaction greatly reduces reaction residence time from 30 min to 1.08 min and maintains high stereo selectivity. The method has the advantages of fast, low energy consumption, continuous and high efficiency, and has good industrialization prospects.

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