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Indexed by:期刊论文

Date of Publication:2006-09-01

Journal:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Included Journals:SCIE、PubMed、Scopus

Volume:41

Issue:9

Page Number:1084-1089

ISSN No.:0223-5234

Key Words:severe acute respiratory syndrome; coronavirus; stilbene derivatives

Abstract:Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 (<= 0.5 mg ml(-1)) and no significant cytotoxic effects were observed in vitro. (c) 2006 Elsevier SAS. All rights reserved.