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冠心膏贴片成型工艺及丹参酮ⅡA的体外释放

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Indexed by:期刊论文

Date of Publication:2007-08-10

Journal:中国医药工业杂志

Included Journals:PKU、ISTIC、CSCD

Volume:38

Issue:8

Page Number:561-563

ISSN No.:1001-8255

Key Words:冠心膏贴片;丙烯酸酯压敏胶;丹参酮ⅡA

Abstract:以丙烯酸酯压敏胶为基质制备冠心膏贴片.通过测定贴片的180°剥离强度和持黏力优化贴片组方,并测定了贴片中丹参酮ⅡA含量以及贴片的体外释放行为.结果表明,贴片的优化组方为:水0.24~0.30g,乙醇0.18~0.24g,丙烯酸树脂0.15g.按优化组方制得的贴片12h体外释放度24.6%,高于市售冠心膏贴剂.

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