Release Time:2025-11-20  Hits:

Date of Publication: 2022-10-06

Journal: 中国药学杂志

Institution: 实验室与设备管理处

Volume: 47

Issue: 8

Page Number: 599-603

ISSN: 1001-2494

Abstract: OBJECTIVE To explore the effect of paeoniflorin on the pharmacokinetics
   of glycyrrhizic acid and its active metabolite glycyrrhetinic acid after
   oral administration.METHODS After the administration of glycyrrhizic
   acid alone or with paeoniflorin,blood samples were collected,and the
   plasma concentration-time profiles of glycyrrhizic acid and
   glycyrrhetinic acid were established.Pharmacokinetic parameters were
   calculated and analyzed with Topfit 2.0 software.RESULTS When
   glycyrrhizic acid was co-administered with paeoniflorin,the rho_(max)
   and AUC of glycyrrhizic acid decreased to 9% and 33% of those of
   glycyrrhizic acid administered alone,respectively;the t_(max) prolonged
   markedly,CL increased,and Vd became larger.For glycyrrhetinic acid,only
   the t_(1/2) prolonged significantly while other PK parameters had little
   change.CONCLUSION Paeoniflorin dramatically inhibits the absorption rate
   and extent of glycyrrhizic acid in rats when simultaneously orally
   administered,but has only small effect on the absorption of
   glycyrrhetinic acid.

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