Release Time:2025-11-20  Hits:

Date of Publication: 2022-10-04

Journal: 中国药学杂志

Volume: 49

Issue: 8

Page Number: 627-631

ISSN: 1001-2494

Abstract: OBJECTIVE To summarize the application of some short peptides which have
   transdermal enhancing activity in recent ten years. METHODS By
   sorting,analyzing and summarizing domestic and foreign literatures,the
   types and characteristics of short peptides,the modes of enhancing
   transdermal drug delivery,enhancing mechanisms, the existing problems
   and direction of future development were reviewed. RESULTS AND
   CONCLUSION Penetrating peptides can help drugs penetrate stratum corneum
   into viable derma or systemic circulation effectively. Compared to
   conventional physical and chemical methods,short peptides,as novel
   biological enhancers,have advantages such as good biocompatibility and
   low toxicity. Meanwhile, short peptides have transdermal enhancing
   activity for biomacromolecules like insulin,which bring hope for
   developing novel administration route of biomacromolecule drugs.

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