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Indexed by:期刊论文

Date of Publication:2009-10-01

Journal:SYNLETT

Included Journals:SCIE、Scopus

Issue:16

Page Number:2659-2662

ISSN No.:0936-5214

Key Words:lappaconitine; asymmetric alpha-hydroxylation; beta-keto esters; organocatalyst; terpenoid alkaloid

Abstract:Discovering organocatalysts with novel framework from terpenoid alkaloids is presented in this paper. Lappaconitine was found to enantioselectively catalyze alpha-hydroxylation of beta-keto esters using tert-butyl hydroperoxide as the oxidant in chloroform to afford the corresponding products in high yields and good enantioselectivity (up to 85% ee).