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发表时间：2022-10-09

发表刊物：药学学报

所属单位：生物工程学院

卷号：49

期号：7

页面范围：1062-1068

ISSN号：0513-4870

摘要：The microstructure of cationic cyclopeptide (TD-34) treated Caco-2 cell
   membrane was observed, and we discussed the relationship between
   membrane structure and insulin transmembrane permeability. Atomic force
   microscope (AFM) was used to observe living cell membrane in air
   condition and tapping mode. Results showed that the surface of Caco-2
   cell membrane treated with TD-34 lost its smoothness and nearly doubled
   its roughness. Apparent permeability coefficients (P_(app)) of insulin
   in Caco-2 cell monolayers increased 2.5 times. In conclusion, AFM can be
   used to observe microstructure of cationic cyclopeptide treated cell
   membrane and cationic cyclopeptide enhanced insulin delivery across
   Caco-2 cell membrane by increasing membrane fluidity.

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