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论文类型：期刊论文

发表时间：2010-10-31

发表刊物：INTERNATIONAL JOURNAL OF PHARMACEUTICS

收录刊物：SCIE、PubMed、Scopus

卷号：399

期号：1-2

页面范围：102-108

ISSN号：0378-5173

关键字：Glycyrrhetinic acid; Transdermal system; Ion pair; Organic base; Non-aqueous solvent

摘要：The aim of the present study was to explore the effects of organic bases and alcohols on the percutaneous absorption of Glycyrrhetinic acid (GA). GA is a metabolite of Glycyrrhizic acid (GL), a major active ingredient of Glycyrrhizae (Gancao) Radices. Skin penetration parameters of GA were obtained via in vitro penetration experiments using intact and stripped mice back skin. Non-aqueous solvent comprising isopropyl myristate (IPM) and alcohols (ethanol, butanol, octanol and dodecanol) loaded with organic base (triethanolamine or triethylamine) were applied to improve the penetration of GA. In order to further confirm the mechanism by which the organic bases enhanced the penetration of GA, conductivity measurement, (1)H NMR spectroscopy and FT-IR analysis were used to observe the formation of ion pair between GA and organic base. The formation of ion pair increased the solubility of GA in the stratum corneum (SC) and its partition into the viable skin, and therefore enhanced the penetration of GA in skin. (C) 2010 Elsevier B.V. All rights reserved.