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论文类型：期刊论文

发表时间：2012-09-28

发表刊物：SCIENCE

收录刊物：Nature、Science、Cell期刊、SCIE、ESI高被引论文、Scopus

卷号：337

期号：6102

页面范围：1640-1644

ISSN号：0036-8075

摘要：A remarkable feature of modern silicon electronics is its ability to remain physically invariant, almost indefinitely for practical purposes. Although this characteristic is a hallmark of applications of integrated circuits that exist today, there might be opportunities for systems that offer the opposite behavior, such as implantable devices that function for medically useful time frames but then completely disappear via resorption by the body. We report a set of materials, manufacturing schemes, device components, and theoretical design tools for a silicon-based complementary metal oxide semiconductor (CMOS) technology that has this type of transient behavior, together with integrated sensors, actuators, power supply systems, and wireless control strategies. An implantable transient device that acts as a programmable nonantibiotic bacteriocide provides a system-level example.