Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2011-09-01

Journal: APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Included Journals: PubMed、EI、SCIE、Scopus

Volume: 165

Issue: 2

Page Number: 485-496

ISSN: 0273-2289

Key Words: Single cells; Single molecules; Atomic force microscopy; Laser tweezers; Raman spectroscopy

Abstract: By using three physical techniques (atomic force microscopy (AFM), laser tweezers, and Raman spectroscopy), many excellent works in single-cell/molecule research have been accomplished. In this review, we present a brief introduction to the principles of these three techniques, and their capabilities toward single-cell/molecule research are highlighted. Afterward, the advances in single-cell/molecule research that have been facilitated by these three techniques are described. Following this, their complementary assets for single-cell/molecule research are analyzed, and the necessity of integrating the functions of these three techniques into one instrument is proposed.