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论文类型：期刊论文

发表时间：2011-09-01

发表刊物：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

收录刊物：Scopus、SCIE、EI、PubMed

卷号：165

期号：2

页面范围：485-496

ISSN号：0273-2289

关键字：Single cells; Single molecules; Atomic force microscopy; Laser tweezers; Raman spectroscopy

摘要：By using three physical techniques (atomic force microscopy (AFM), laser tweezers, and Raman spectroscopy), many excellent works in single-cell/molecule research have been accomplished. In this review, we present a brief introduction to the principles of these three techniques, and their capabilities toward single-cell/molecule research are highlighted. Afterward, the advances in single-cell/molecule research that have been facilitated by these three techniques are described. Following this, their complementary assets for single-cell/molecule research are analyzed, and the necessity of integrating the functions of these three techniques into one instrument is proposed.