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论文类型：期刊论文

发表时间：2016-01-01

发表刊物：NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE

收录刊物：SCIE、EI、PubMed、Scopus

卷号：12

期号：1

页面范围：235-244

ISSN号：1549-9634

关键字：Fe-filled carbon nanotube; Contrast agent; Thermoacoustic molecular imaging; MRI; Targeted tumor imaging

摘要：Microwave-induced thermoacoustic imaging (TAI) can map the microwave absorption distribution of targets, which depends on the electrical and magnetic properties. Although carbon nanotubes (CNTs) with good electrical properties have been used as TAI contrast agents, the negligible magnetic absorption hinders its application for sensitive detection. In order to exploit CNTs with electrical and magnetic absorption properties as agent of TAI, the ferromagnetic material-filled multi-walled CNTs (MMWCNTs) are investigated. In this study, the folic acid conjugated plain multiwalled CNTs (MWCNTs) and MMWCNTs were injected through the tail-vein of mice separately, and TAI and magnetic resonance imaging (MRI) were performed. The results show the MMWCNTs can clearly image the size and edge of the tumor with the TAI contrast enhancement of 67% and T-2 signal intensity decrease of four fifths compared to MWCNTs. This study demonstrated the hybrid particles have the potential to be a high-sensitive contrast agent for accurate tumor detection.
   From the Clinical Editor: Novel imaging modalities are emerging. Microwave-induced thermoacoustic imaging (TAI) relies on the absorption distribution of microwave of targets. In this article the authors investigate the use of ferromagnetic material-filled multi-walled CNTs as contrast agents for both TAI and MRI in an in-vivo model for tumors. The positive findings would imply that the application of dual-modality probe could provide more accurate imaging for the clinical setting. (C) 2015 Elsevier Inc. All rights reserved.