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论文类型：期刊论文

发表时间：2015-01-01

发表刊物：Numerical Algebra, Control and Optimization

收录刊物：Scopus

卷号：5

期号：4

页面范围：393-403

ISSN号：21553289

摘要：The background of this paper is the production of 1,3-PD by batch fermentation of glycerol, supposed that glycerol and 1,3-PD pass the cell membrane by passive diffusion with active transportation. We present a nonlinear enzyme-catalytic dynamical system with genetic regulation and our purpose is to identify these parameters in the dynamical system. Since the intracel-lular substance concentrations are immeasurable, we refer to the robustness definition of parameter disturbance in biological system, then we establish a parameter identification model. We prove the existence of the solution to the optimization model. At last, we get the parameters of dynamical systems by particle swarm algorithm. Numerical results show that the optimization algorithm is valid and the genetic regulations can help to understand the intracellular reaction process. ? 2015, American Institute of Mathematical Sciences. All rights reserved.