Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2018-05-10

Journal: TETRAHEDRON

Included Journals: SCIE

Volume: 74

Issue: 19

Page Number: 2369-2375

ISSN: 0040-4020

Key Words: Spirooxindole; Indolenine; 1,3-Dipolar cycloaddition; Azomethine ylide; Regioselectivity

Abstract: An organic base-catalyzed 1,3-dipolar cycloaddition between 2-alkenylindolenines and azomethine ylides derived from isatins and benzylamines was successfully developed to assemble indolenine-substituted spiro [pyrrolidine-2,3'-oxindole] ring systems. Generally, good regioselectivities (up to 14:1 rr) and high yields (up to 91%) were obtained under mild conditions. (C) 2018 Elsevier Ltd. All rights reserved.