Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2018-02-25

Journal: Chemical communications (Cambridge, England)

Included Journals: SCIE

Volume: 54

Issue: 16

Page Number: 2028-2031

ISSN: 1364-548X

Abstract: A catalytic asymmetric Michael addition/annulation process between pyrazolones and enynones towards enantioenriched pyranopyrazoles was developed. Key features include the development of a cinchona alkaloid with C6' steric bulk as a competent catalyst and the observation of a unique stereospecific deuteration alpha to the keto group via a conducted tour pathway.