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Substrate-controlled divergent synthesis of polycyclic indoloazepines and indolodiazepines via 1,5-hydride shift/7-cyclization cascades

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Indexed by:期刊论文

Date of Publication:2018-07-21

Journal:CHEMICAL COMMUNICATIONS

Included Journals:SCIE

Volume:54

Issue:57

Page Number:7928-7931

ISSN No.:1359-7345

Abstract:Novel and practical acid-catalyzed cyclization of 2-indolyl aryl carbinols via tandem dehydration/1,5-hydride shift/7-cyclization sequences has been developed. By appropriate variation of the substrate, diverse polycyclic-fused indoles were synthesized in good yield, thus demonstrating the high efficiency, transition-metal-free nature, and high step/atom economy of the synthesis strategy.

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