Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2018-09-14

Journal: ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals: SCIE

Volume: 16

Issue: 34

Page Number: 6275-6283

ISSN: 1477-0520

Abstract: An iodine-mediated alkenylation of pyrazolones with simple alkenes under an air atmosphere has been developed. By this protocol, the pharmaceutically relevant pyrazolone scaffold was directly adorned with a readily transformable olefinic functional group through a cross-dehydrogenative coupling process in moderate to excellent yields. The coupling products could be facilely manipulated by, for example, the Heck reaction and hydrogenation treatment, thus enriching the pyrazolone derivatives. Based on the observation of the reaction intermediate and mechanistical experiments, two possible reaction pathways were proposed.