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Indexed by:期刊论文

Date of Publication:2016-12-01

Journal:ADVANCED SYNTHESIS & CATALYSIS

Included Journals:SCIE、Scopus

Volume:358

Issue:24

Page Number:3971-3976

ISSN No.:1615-4150

Key Words:asymmetric catalysis; Cinchona alkaloids; hydroxylation; pyrazolones

Abstract:A natural quinine-catalyzed, efficient and practical asymmetric -hydroxylation of 4-substituted pyrazolones has been developed, delivering a broad spectrum of pyrazolones bearing an oxygen-attached carbon stereocenter at C-4 in high yields and excellent enantioselectivities. The broad substrate scope, ready availability of the catalyst, ease of operation, and valuable transformation of the product highlight the practical utility of this process.