Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2016-12-01

Journal: ADVANCED SYNTHESIS & CATALYSIS

Included Journals: Scopus、SCIE

Volume: 358

Issue: 24

Page Number: 3971-3976

ISSN: 1615-4150

Key Words: asymmetric catalysis; Cinchona alkaloids; hydroxylation; pyrazolones

Abstract: A natural quinine-catalyzed, efficient and practical asymmetric -hydroxylation of 4-substituted pyrazolones has been developed, delivering a broad spectrum of pyrazolones bearing an oxygen-attached carbon stereocenter at C-4 in high yields and excellent enantioselectivities. The broad substrate scope, ready availability of the catalyst, ease of operation, and valuable transformation of the product highlight the practical utility of this process.