Release Time:2019-03-12  Hits:

Indexed by: Journal Article

Date of Publication: 2016-11-01

Journal: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Included Journals: SCIE

Issue: 32

Page Number: 5335-5339

ISSN: 1434-193X

Key Words: Cycloaddition; Diastereoselectivity; Heterocycles; Multicomponent reactions; Spiro compounds

Abstract: A three-component [3+2] cycloaddition involving 3-aminooxindoles, aldehydes, and methyleneindolinone derivatives for the synthesis of dispiro[pyrrolidine-2,3'-oxindole] derivatives was developed. This reaction involves the use of readily available starting materials and mild reaction conditions. It displays broad functional-group tolerance and provides the products in high yields with good to excellent diastereoselectivities.