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Indexed by:期刊论文

Date of Publication:2016-11-01

Journal:EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Included Journals:SCIE

Issue:32

Page Number:5335-5339

ISSN No.:1434-193X

Key Words:Cycloaddition; Diastereoselectivity; Heterocycles; Multicomponent reactions; Spiro compounds

Abstract:A three-component [3+2] cycloaddition involving 3-aminooxindoles, aldehydes, and methyleneindolinone derivatives for the synthesis of dispiro[pyrrolidine-2,3'-oxindole] derivatives was developed. This reaction involves the use of readily available starting materials and mild reaction conditions. It displays broad functional-group tolerance and provides the products in high yields with good to excellent diastereoselectivities.