Release Time:2019-03-13  Hits:

Indexed by: Journal Article

Date of Publication: 2016-09-15

Journal: CHEMICAL COMMUNICATIONS

Included Journals: Scopus、PubMed、SCIE

Volume: 52

Issue: 76

Page Number: 11426-11429

ISSN: 1359-7345

Abstract: A natural quinidine-catalyzed asymmetric chlorination of 4-substituted pyrazolones is developed, affording products with a quaternary chiral chlorine-attached carbon centre in high yield with excellent enantio-selectivity. The low catalyst loading (1 mol%), broad substrate scope, and facile and valuable transformation of the product highlight the practical utility of this process.