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Indexed by:期刊论文

Date of Publication:2015-04-01

Journal:EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Included Journals:SCIE、Scopus

Volume:2015

Issue:10

Page Number:2143-2147

ISSN No.:1434-193X

Key Words:Isoxazolinone; Organocatalysis; Cinchona alkaloid; Fluorine; Heterocycles

Abstract:A straightforward method for the asymmetric fluorination of 4-substituted isoxazolinones catalyzed by a bis-cinchona alkaloid catalyst was developed. A series of 4-fluoroisoxazolinone derivatives with a fluorine-containing quaternary stereocenter were obtained in good to high yields with good enantioselectivities (up to 91% yield, 85% ee).