Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2015-04-01

Journal: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Included Journals: Scopus、SCIE

Volume: 2015

Issue: 10

Page Number: 2143-2147

ISSN: 1434-193X

Key Words: Isoxazolinone; Organocatalysis; Cinchona alkaloid; Fluorine; Heterocycles

Abstract: A straightforward method for the asymmetric fluorination of 4-substituted isoxazolinones catalyzed by a bis-cinchona alkaloid catalyst was developed. A series of 4-fluoroisoxazolinone derivatives with a fluorine-containing quaternary stereocenter were obtained in good to high yields with good enantioselectivities (up to 91% yield, 85% ee).