Catalytic asymmetric construction of spiro[pyrrolidine-2,3 '-oxindole] scaffolds through chiral phosphoric acid-catalyzed 1,3-dipolar cycloaddition involving 3-amino oxindoles
Release Time:2019-03-09 Hits:
Indexed by: Journal Article
Date of Publication: 2015-11-04
Journal: CHEMICAL COMMUNICATIONS
Included Journals: Scopus、PubMed、SCIE
Volume: 51
Issue: 85
Page Number: 15510-15513
ISSN: 1359-7345
Abstract: The catalytic asymmetric three-component 1,3-dipolar cycloaddition of 3-amino oxindoles with aldehydes and nitroolefins under the catalysis of a chiral phosphoric acid is reported. The reaction provides a facile approach to synthesize a diverse array of spiro[pyrrolidine-2,3'-oxindoles] in high yields with excellent diastereo-and enantioselectivities under mild conditions.
Prev One:An Organocatalytic Asymmetric Friedel-Crafts Addition/Fluorination Sequence: Construction of Oxindole-Pyrazolone Conjugates Bearing Vicinal Tetrasubstituted Stereocenters
Next One:Synthesis and Electrocatalytic Property of Diiron Hydride Complexes Derived from a Thiolate-Bridged Diiron Complex