Zinc chloride catalyzed stereoselective construction of spiropyrazolone tetrahydroquinolines via tandem [1,5]-hydride shift/cyclization sequence
Release Time:2019-03-09 Hits:
Indexed by: Journal Article
Date of Publication: 2015-01-01
Journal: RSC ADVANCES
Included Journals: Scopus、EI、SCIE
Volume: 5
Issue: 105
Page Number: 86056-86060
ISSN: 2046-2069
Abstract: A zinc chloride catalyzed tandem 1,5-hydride shift/cyclization process to form spiropyrazolone terahydroquinoline derivatives is developed. A series of new spiropyrazolone derivatives were obtained in good to high yields with good to excellent diastereoselectivities (up to 95% yield, >95 : 5 dr). Additionally, the spiropyrazolone derivatives could be converted into the corresponding novel spriopyrazolines.