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Indexed by:期刊论文

Date of Publication:2014-12-07

Journal:ORGANIC & BIOMOLECULAR CHEMISTRY

Included Journals:PubMed、SCIE、Scopus

Volume:12

Issue:45

Page Number:9097-9100

ISSN No.:1477-0520

Abstract:We report a highly efficient approach to constructing chiral N,S-acetals using 5-substituted rhodanines as sulfur-bound pronucleophiles catalyzed by natural cinchona alkaloids quinine or quinidine. This alpha-amination reaction has a broad substrate scope, and the products featuring both rhodanine and N,S-acetal structural motifs were obtained in high yields and excellent enantioselectivities.