Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2013-06-21

Journal: ORGANIC LETTERS

Included Journals: Scopus、PubMed、SCIE

Volume: 15

Issue: 12

Page Number: 3106-3109

ISSN: 1523-7060

Abstract: A novel library of chiral guanidines featuring a tartaric acid skeleton was developed from diethyl L-tartrate. These guanidines are easily accessed with tunable style and electronic properties. The utilities of the guanidines were highlighted by their ability to catalyze the alpha-hydroxylation of beta-ketoesters and beta-diketones with remarkable efficiency and excellent enantioselectivity.