Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2012-06-01

Journal: ORGANIC LETTERS

Included Journals: Scopus、PubMed、SCIE

Volume: 14

Issue: 11

Page Number: 2734-2737

ISSN: 1523-7060

Abstract: The first highly enantio- and diastereoselective vinylogous aldol reaction between propionyl acetate-derived Brassard's diene and aldehydes was accomplished by titanium lithium combined Lewis acid, affording delta-hydroxy-gamma-methyl-beta-methoxy acrylates. This methodology was utilized in convenient and concise construction of the polypropionate moiety in cystothiazole A and mellthiazole C.