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Indexed by:期刊论文

Date of Publication:2010-12-01

Journal:JOURNAL OF CHEMICAL RESEARCH

Included Journals:SCIE、Scopus

Volume:34

Issue:12

Page Number:684-688

ISSN No.:1747-5198

Key Words:Protox-inhibitor; pyrazoles; herbicidal activity; synthesis

Abstract:To search for novel Protox inhibitors, a series of phenyl and 1,4-benzoxazin-5-yl pyrazole derivatives were synthesised from 3-(4-chloro-2-fluoro-5-methoxyphenyl)-1-methyl-5-trifluoromethyl-1H-pyrazole or its halogen substituted derivatives, via a serial of reactions that included nitration, reduction, acetylation, ring closure, methylation, etc. The single crystal of 2-(N-acetylacetamido)-6-chloro-3-[4-chloro-5-(trifluoromethyl)-1-methyl-1H-pyrazol-3-yl]-4-fluorophenyl acetate was prepared, and its structure was determined by X-ray analysis. The preliminary bioassay test shows that some of the compounds have high bioactivity. Especially, even at a low dosage of 150 g hm(-2), 2-(N-acetylacetamido)-6-chloro-3-[4-chloro-5-(trifluoromethyl)-1-methyl-1H-pyrazol-3-yl]-4-fluorophenyl acetate exhibited high activity, the inhibiting rate for both of the weeds reached above 90%.