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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本东京大学
学位：博士
所在单位：化工学院
电子邮箱：qujp@dlut.edu.cn
Assembly of Indolenines, 3-Amino Oxindoles, and Aldehydes into Indolenine-Substituted Spiro[pyrrolidin-2,3 '-oxindoles] via 1,3-Dipolar Cycloaddition with Divergent Diastereoselectivities
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论文类型：期刊论文
发表时间：2017-04-21
发表刊物：JOURNAL OF ORGANIC CHEMISTRY
收录刊物：EI、PubMed、SCIE
卷号：82
期号：8
页面范围：4317-4327
ISSN号：0022-3263
摘要：A novel one-pot 1,3-dipolar cycloaddition of indolenines, 3-aminooxindoles, and aldehydes is reported. The reaction provides indolenine-substituted spiro [pyrrolidin-2,3 '-oxindoles] containing four contiguous stereogenic centers in high yields (up to 99%) and excellent diastereoselectivities (up to > 20:1 dr) under mild conditions. Remarkably, the inversion of diastereoselectivity could be readily achieved through slightly modifying the reaction conditions.
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