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论文类型：期刊论文

发表时间：2016-12-01

发表刊物：ADVANCED SYNTHESIS & CATALYSIS

收录刊物：SCIE、Scopus

卷号：358

期号：24

页面范围：3971-3976

ISSN号：1615-4150

关键字：asymmetric catalysis; Cinchona alkaloids; hydroxylation; pyrazolones

摘要：A natural quinine-catalyzed, efficient and practical asymmetric -hydroxylation of 4-substituted pyrazolones has been developed, delivering a broad spectrum of pyrazolones bearing an oxygen-attached carbon stereocenter at C-4 in high yields and excellent enantioselectivities. The broad substrate scope, ready availability of the catalyst, ease of operation, and valuable transformation of the product highlight the practical utility of this process.