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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本东京大学
学位：博士
所在单位：化工学院
电子邮箱：qujp@dlut.edu.cn
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A ZnCl2-Catalyzed Knoevenagel Condensation/1,5-Hydride Shift/Cyclization Sequence: Synthesis of Novel Spiroisoxazol-5-one Tetrahydroquinolines
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论文类型：期刊论文
发表时间：2016-08-16
发表刊物：CHEMISTRYSELECT
收录刊物：SCIE
卷号：1
期号：13
页面范围：3713-3717
ISSN号：2365-6549
关键字：1,5-H shift; spiroisoxazol-5-one; tetrahydroquinoline; zinc chloride
摘要：A concise synthesis of novel spiroisoxazol-5-one tetrahydroquinoline derivatives has been developed by an efficient ZnCl2-catalyzed stereoselective Knoevenagel Condensation/1,5-hydride shift/cyclization sequence. The reactions are broad in scope and the products could be obtained in good to high yields (up to 97% yield) with good to excellent diaster-eoselectivities (up to >95:5 dr). In addition, these products may be converted into novel 5-hydroxy-spiroisoxazolines and spiropyrazolones.