曲景平
个人信息Personal Information
教授
博士生导师
硕士生导师
性别:男
毕业院校:日本东京大学
学位:博士
所在单位:化工学院
电子邮箱:qujp@dlut.edu.cn
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Organocatalytic enantioselective alpha-amination of 5-substituted rhodanines: an efficient approach to chiral N,S-acetals
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论文类型:期刊论文
发表时间:2014-12-07
发表刊物:ORGANIC & BIOMOLECULAR CHEMISTRY
收录刊物:PubMed、SCIE、Scopus
卷号:12
期号:45
页面范围:9097-9100
ISSN号:1477-0520
摘要:We report a highly efficient approach to constructing chiral N,S-acetals using 5-substituted rhodanines as sulfur-bound pronucleophiles catalyzed by natural cinchona alkaloids quinine or quinidine. This alpha-amination reaction has a broad substrate scope, and the products featuring both rhodanine and N,S-acetal structural motifs were obtained in high yields and excellent enantioselectivities.