Organocatalytic enantioselective alpha-amination of 5-substituted rhodanines: an efficient approach to chiral N,S-acetals
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论文类型：期刊论文
发表时间：2014-12-07
发表刊物：ORGANIC & BIOMOLECULAR CHEMISTRY
收录刊物：Scopus、SCIE、PubMed
卷号：12
期号：45
页面范围：9097-9100
ISSN号：1477-0520
摘要：We report a highly efficient approach to constructing chiral N,S-acetals using 5-substituted rhodanines as sulfur-bound pronucleophiles catalyzed by natural cinchona alkaloids quinine or quinidine. This alpha-amination reaction has a broad substrate scope, and the products featuring both rhodanine and N,S-acetal structural motifs were obtained in high yields and excellent enantioselectivities.