Novel Tartrate-Based Guanidines for Enantioselective Fluorination of 1,3-Dicarbonyl and alpha-Cyano Carbonyl Compounds
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论文类型：期刊论文
发表时间：2014-01-01
发表刊物：AUSTRALIAN JOURNAL OF CHEMISTRY
收录刊物：Scopus、EI、SCIE
卷号：67
期号：7
页面范围：1115-1118
ISSN号：0004-9425
摘要：A novel library of chiral guanidines featuring the tartaric acid skeleton is easily accessed with tunable steric and electronic properties. A guanidine molecule of this library with an incorporated 2,6-diisoaniline fragment was identified as a suitable promoter for the enantioselective fluorination of 1,3-dicarbonyl and alpha-cyano carbonyl compounds to furnish the fluorinated product with up to 84% ee and 99% yield using N-fluorobenzenesulfonimide (NFSI) as the fluorinating agent.