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论文类型：期刊论文

发表时间：2013-04-19

发表刊物：JOURNAL OF ORGANIC CHEMISTRY

收录刊物：SCIE、EI、PubMed、Scopus

卷号：78

期号：8

页面范围：4171-4176

ISSN号：0022-3263

摘要：A highly efficient, operationally simple approach to trifluoromethyl ketones has been developed that builds on the use of a tandem process involving Claisen condensation and retro-Claisen C-C bond cleavage reaction. Enolizable alkyl phenyl ketones were found to react readily with ethyl trifuoroacetate under the promotion of NaH to afford trifluoroacetic ester/ketone exchange products, trifluoromethyl ketones, which were quite different from the general Claisen condensation products, beta-diketones. This procedure uses readily available starting materials and can be extended to the preparation of perfluoroalkyl ketones in excellent yield.