Carbonylative Sonogashira Coupling of Aryl Iodides with Terminal Alkynes Catalyzed by Palladium Nanoparticles
Release Time:2019-03-12 Hits:
Indexed by: Journal Article
Date of Publication: 2018-03-01
Journal: JOURNAL OF THE CHINESE CHEMICAL SOCIETY
Included Journals: CPCI-S、SCIE
Volume: 65
Issue: 3,SI
Page Number: 337-345
ISSN: 0009-4536
Key Words: Palladium nanoparticles; alpha,beta-Alkynyl ketones; Carbonylative Sonogashira coupling
Abstract: A convenient and efficient method for the synthesis of a, beta-alkynyl ketones from the three-component coupling of aryl iodides, terminal alkynes, and carbon monoxide (carbonylative Sonogashira coupling reaction) is successfully developed. The carbonylative Sonogashira coupling reaction proceeded smoothly under mild conditions in the presence of palladium nanoparticles to produce the corresponding a, beta-alkynyl ketones in good to excellent yields.