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Synthesis of 3,5-Disubstituted Isoxazoles via Cope-Type Hydroamination of 1,3-Dialkynes

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Indexed by:期刊论文

Date of Publication:2012-05-04

Journal:ORGANIC LETTERS

Included Journals:SCIE、PubMed、Scopus

Volume:14

Issue:9

Page Number:2418-2421

ISSN No.:1523-7060

Abstract:An efficient method for the synthesis of 3,5-disubstituted Isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles In satisfactory to excellent yields.

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