Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2011-08-19

Journal: JOURNAL OF ORGANIC CHEMISTRY

Included Journals: PubMed、EI、SCIE

Volume: 76

Issue: 16

Page Number: 6901-6905

ISSN: 0022-3263

Abstract: An efficient method for synthesizing N,N-di-methylpropargylamines is described. The synthesis exploited the Cu(II)-catalyzed oxidative alkynylation reaction of tri-methylamine N-oxides with alkynes in the absence of external oxidant. Both aromatic and aliphatic allcynes were utilized to achieve the corresponding products in moderate to excellent yields. The reaction conditions tolerated ester, hydroxy, and aldehyde groups.