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个人信息Personal Information
教授
博士生导师
硕士生导师
性别：男
毕业院校：日本东北大学
学位：博士
办公地点：精细化工国家重点实验室E504
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An efficient transformation of primary halides into nitriles through palladium-catalyzed hydrogen transfer reaction
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论文类型：期刊论文
发表时间：2015-07-07
发表刊物：CHEMICAL COMMUNICATIONS
收录刊物：Scopus、PubMed、SCIE
卷号：51
期号：53
页面范围：10714-10717
ISSN号：1359-7345
摘要：Two-step one-pot transformation of primary halides into corresponding nitriles is successfully achieved. Nucleophilic substitution of primary halides with sodium azide and subsequent palladium-catalyzed hydrogen transfer proceeds smoothly in the presence of sterically bulky ligand dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine (XPhos) in acetone to produce nitriles in satisfactory to good yields.