Hits:

Indexed by:期刊论文

Date of Publication:2014-09-01

Journal:SYNTHESIS-STUTTGART

Included Journals:SCIE、EI、Scopus

Volume:46

Issue:18

Page Number:2422-2429

ISSN No.:0039-7881

Key Words:1,3,5-trisubstituted pyrazole; 1,3-dialkyne; alkylhydrazine; synthesis; Cope-type hydroamination

Abstract:An efficient method to synthesize 1,3,5-trisubstituted pyrazoles was developed. The reaction of 1,3-dialkynes with alkylhydrazines smoothly proceeded in dimethyl sulfoxide under suitable heating conditions to produce 1,3,5-trisubstituted pyrazoles in satisfactory to excellent yields.