Synthesis of 1,3,5-Trisubstituted Pyrazoles by the Cope-Type Hydroamination of 1,3-Dialkynes with Alkylhydrazines
Release Time:2019-03-09 Hits:
Indexed by: Journal Article
Date of Publication: 2014-09-01
Journal: SYNTHESIS-STUTTGART
Included Journals: Scopus、EI、SCIE
Volume: 46
Issue: 18
Page Number: 2422-2429
ISSN: 0039-7881
Key Words: 1,3,5-trisubstituted pyrazole; 1,3-dialkyne; alkylhydrazine; synthesis; Cope-type hydroamination
Abstract: An efficient method to synthesize 1,3,5-trisubstituted pyrazoles was developed. The reaction of 1,3-dialkynes with alkylhydrazines smoothly proceeded in dimethyl sulfoxide under suitable heating conditions to produce 1,3,5-trisubstituted pyrazoles in satisfactory to excellent yields.