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Copper-catalyzed aldol-type addition of ketones to aromatic nitriles: a simple approach to enaminone synthesis

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Indexed by:期刊论文

Date of Publication:2013-04-11

Journal:CHEMICAL COMMUNICATIONS

Included Journals:SCIE、PubMed、Scopus

Volume:49

Issue:28

Page Number:2885-2887

ISSN No.:1359-7345

Abstract:An efficient method for the synthesis of enaminones is described. The aldol-type addition of ketones to aromatic nitriles proceeded smoothly in the presence of a simple copper catalyst system (CuI-2,2'-bipyridine-(NaOBu)-Bu-t) in N,N-dimethylformamide. Enaminones in satisfactory to excellent yields were produced using this technique.

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