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Oxidative Coupling of Indoles with Ethyl 2-(Disubstituted Amino)Acetates: An Approach to Achieve Indolylglycine Derivatives

Release Time:2019-03-09  Hits:

Indexed by: Journal Article

Date of Publication: 2012-08-17

Journal: JOURNAL OF ORGANIC CHEMISTRY

Included Journals: Scopus、PubMed、EI、SCIE

Volume: 77

Issue: 16

Page Number: 7114-7118

ISSN: 0022-3263

Abstract: An efficient method for the synthesis of indolylglycine derivatives is described. The oxidative coupling reactions of ethyl 2-(disubstituted amino)acetates with indoles proceeded smoothly in the presence of meta-chloroperoxybenzoic acid (mCPBA) under ambient conditions to produce indolylglycine derivatives in satisfactory to excellent yields.

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