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Oxidative Coupling of Indoles with Ethyl 2-(Disubstituted Amino)Acetates: An Approach to Achieve Indolylglycine Derivatives

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Indexed by:期刊论文

Date of Publication:2012-08-17

Journal:JOURNAL OF ORGANIC CHEMISTRY

Included Journals:SCIE、EI、PubMed、Scopus

Volume:77

Issue:16

Page Number:7114-7118

ISSN No.:0022-3263

Abstract:An efficient method for the synthesis of indolylglycine derivatives is described. The oxidative coupling reactions of ethyl 2-(disubstituted amino)acetates with indoles proceeded smoothly in the presence of meta-chloroperoxybenzoic acid (mCPBA) under ambient conditions to produce indolylglycine derivatives in satisfactory to excellent yields.

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