论文成果
Synthesis of 2-Naphthols via Carbonylative Stille Coupling Reaction of 2-Bromobenzyl Bromides with Tributylallylstannane Followed by the Heck Reaction
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- 论文类型：期刊论文
- 发表时间：2011-12-16
- 发表刊物：JOURNAL OF ORGANIC CHEMISTRY
- 收录刊物：Scopus、SCIE、PubMed
- 文献类型：J
- 卷号：76
- 期号：24
- 页面范围：10068-10077
- ISSN号：0022-3263
- 摘要：A method for the synthesis of 2-naphthols 4 is described. The carbonylative Stifle coupling reactions of 2-bromobenzyl bromides with tributylallylstannane to produce 2-bromobenzyl beta,gamma-unsaturated ketones 2 in satisfactory to excellent yields has been achieved. The isomerization of 2-bromobenzyl beta,gamma-unsaturated ketones 2 can readily occur under basic conditions to generate 2-bromobenzyl alpha,beta-unsaturated ketones 3. The 2-bromobenzyl alpha,beta-unsaturated ketones 3 can be transformed into 2-naphthols 4 via intramolecular Heck reaction in satisfactory to good yields.
