个人信息Personal Information
教授
博士生导师
硕士生导师
性别:女
毕业院校:大连理工大学
学位:博士
所在单位:化工学院
办公地点:西部校区实验楼E506
联系方式:0411-84986181
电子邮箱:fengxiujuan@dlut.edu.cn
Synthesis of 2-Naphthols via Carbonylative Stille Coupling Reaction of 2-Bromobenzyl Bromides with Tributylallylstannane Followed by the Heck Reaction
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论文类型:期刊论文
发表时间:2011-12-16
发表刊物:JOURNAL OF ORGANIC CHEMISTRY
收录刊物:Scopus、SCIE、PubMed
卷号:76
期号:24
页面范围:10068-10077
ISSN号:0022-3263
摘要:A method for the synthesis of 2-naphthols 4 is described. The carbonylative Stifle coupling reactions of 2-bromobenzyl bromides with tributylallylstannane to produce 2-bromobenzyl beta,gamma-unsaturated ketones 2 in satisfactory to excellent yields has been achieved. The isomerization of 2-bromobenzyl beta,gamma-unsaturated ketones 2 can readily occur under basic conditions to generate 2-bromobenzyl alpha,beta-unsaturated ketones 3. The 2-bromobenzyl alpha,beta-unsaturated ketones 3 can be transformed into 2-naphthols 4 via intramolecular Heck reaction in satisfactory to good yields.
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